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Comprehensive analysis of putrescine metabolism in A thaliana using GWAS, genetic risk score, metabolic modelling and data mining
Schwarzerová, Jana ; Bartoň, Vojtěch ; Walther, Dirk ; Weckwerth, Wolfram
Polyamines are known to be functionally involvedin plant responses to stress conditions. Despite a large amount ofphysiological and genetic data, the mode of action of polyamines,especially putrescine, at the molecular level still remains unclear.An increasing number of studies point to a role of putrescine instress defense of plants due to influencing the formation of reactiveoxygen species (ROS) in cellular stress conditions. Moreover,putrescine has been found to modulate abscisic acid (ABA)biosynthesis at the transcriptional level in response to lowtemperature, revealing a novel mode of action of polyamines asregulators of hormone biosynthesis. This study presents a newholistic approach towards the analysis of putrescine metabolismusing genome-wide association studies and the calculation ofgenetic risk scores extended by Boolean analysis in metabolitesnetwork as well as data mining from available databases andliterature. It can lead to a better understanding of biologicalprocesses involved in adaptation of plants to environmentalchanges.
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Imunogenetické principy reakce mléčné žlázy na patogeny u skotu
Benešová, Magdalena
Bovine mastitis is the most common bovine disease. IR genes (Immune response genes) are used to resist the immune response. The aim of this work is to describe these genes and their role in immune responses. The complexity of immune responses and resistant polygenic features make it difficult to understand all future comers in the mammary gland. The immune responses describe the components of cellular and humoral immunity that are involved in the defense of the mammary gland. Identification of genomic variants associated with resistance is still trying to find and identify other genes that affect mastitis. Whole genome association studies (GWAS), which use SNP fields, are a valuable tool in these studies. This method uses the phenotypic and genotypic characteristics of individuals. Thanks to GWAS several candidate genes for bovine mastitis resistance have already been identified.
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The genetics of type II diabetes
Svobodová, Kristýna ; Ehler, Edvard (advisor) ; Pavlasová, Lenka (referee)
The bachelor thesis The genetics of type II diabetes is compound of several chapter. The major part is general characteristic of diabetes, diagnostics and pathogenesis. The thesis includes history of diabetes too. The last two chapters are focus on genetics. There are many knowledges which have been gained so far and objects future studies. Very interesting is chapter about genetics studies in variol continents, studies of ethnic groups. Key words Diabetes mellitus I., Diabetes mellitus II., disease, genetics, gen, locus, genome-wide association studies, heritability
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The genetics of type II diabetes
Svobodová, Kristýna ; Ehler, Edvard (advisor) ; Pavlasová, Lenka (referee)
The bachelor thesis The genetics of type II diabetes is compound of several chapter. The major part is general characteristic of diabetes, diagnostics and pathogenesis. The thesis includes history of diabetes too. The last two chapters are focus on genetics. There are many knowledges which have been gained so far and objects future studies. Very interesting is chapter about genetics studies in variol continents, studies of ethnic groups. Key words Diabetes mellitus I., Diabetes mellitus II., disease, genetics, gen, locus, genome-wide association studies, heritability
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